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Women's Health Initiative (WHI) Study 1 | Women's Health Initiative (WHI) Study 1 |
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Synthetic Hormone Replacement Therapy and the Women’s Health Initiative (WHI) Study 1 This study, released in July 2002, was created to address the issue
of whether post-menopausal women with their uteruses still intact
require Hormone Replacement Therapy (HRT) to prevent the development of
chronic disease. More than sixteen thousand women were given synthetic
conjugated estrogen substances (Premarin) plus progestin (Provera).
These women were monitored beginning in 1993. The study was intended to
continue for 8.5 years; however, in May of 2002, after 5.2 years of
follow-up, the regulatory and safety monitoring board recommended to
stop the trial early. 3.Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from Women’s Health Initiative Randomized Controlled Trial. JAMA 2002:288 (3): 321-33.
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